发给老马备查:
$ ]. m( R" E) S6 S滴水察海(69304838) 15:23:23) ~/ q3 \! T: z- C4 b
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱& w/ X" m2 ^2 Q( t; m, [
吉非替尼和S-1连用的依据
) F: l; R6 n; x% FGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
. p0 W8 }" o7 O* }; ]8 l( ]4 ^& A5 Q$ f是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
- _5 z: Z! r/ E; p* p4 s' {这样是不是推理出,耐药后,可以用S-1和培美了?8 x3 u* O _# C# ?8 J+ \2 q
结论:
8 x, z. b7 g2 I& m如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |