发给老马备查:
* _% T% V9 H0 K* G6 y+ L4 H滴水察海(69304838) 15:23:23
9 d' B5 J0 k; M4 k' F& [: q- V老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 I" y+ r7 B- ?8 @, W0 K
吉非替尼和S-1连用的依据) D: u9 r7 T1 W4 [2 q I) _
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.+ x8 @" G0 a# o- W
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
( k: i5 R, T0 _这样是不是推理出,耐药后,可以用S-1和培美了?
$ `, d2 j9 l* v5 M7 S结论:6 h0 l% `6 M; T8 }
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |